Regulatory T (Treg) cells are critical for tolerance to self-antigens and preventing autoimmunity. Their differentiation and function are controlled by transcription factor Foxp3, but mechanistic understanding of Foxp3 role remains elusive. Using functional genomic analysis, we explored Foxp3 function and its interaction with a highly expressed closely related factor Foxp1. We are now studying the role of Foxp3 and other factors in chromatin organization of Treg cells.

Yuri Pritykin
Yuri Pritykin
Assistant Professor of Computer Science and Genomics