Latest

• Changing minds: How AI is transforming the life sciences
• Sequence-to-function modeling uncovers the context-specific grammar of Drosophila chromatin insulation
• Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors
• ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories
• Shared binding sites for the chromosomal architectural protein Su(Hw) mediate physical interactions between Drosophila TAD boundaries
• A community machine learning challenge to predict the effects of gene perturbations on T cell differentiation for cancer immunotherapy
• Eosinophils drive intestinal remodelling and innate defence in reproduction
• Metadomain and metaloop genome interactions in mammalian T cells
• Predictive modeling of molecular activity underlying physical cell-cell interactions
• Benchmarking cell type deconvolution in spatial transcriptomics and application to cancer immunotherapy
• Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
• 3D chromatin structures precede genome activation in Drosophila embryogenesis
• Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
• Cathelicidin antimicrobial peptides mediate immune protection in marsupial neonates
• Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2
• Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia
• Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
• Engineered extrachromosomal oncogene amplifications promote tumorigenesis
• Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis
• Multicenter integrated analysis of noncoding CRISPRi screens
• Universal recording of immune cell interactions in vivo
• Lessons for the next generation of scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium
• Genomic analysis of Foxp3 function in regulatory T cells
• Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells
• Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families
• Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy
• A unified atlas of CD8 T cell dysfunctional states in cancer and infection
• FXR mediates T cell-intrinsic responses to reduced feeding during infection
• High-Resolution in vivo identification of miRNA targets by Halo-enhanced Ago2 pull-down
• Transcriptional basis of mouse and human dendritic cell heterogeneity
• Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function
• Epigenetic control of innate and adaptive immune memory
• Non-redundant ISGF3 components promote NK cell survival in an auto-regulatory manner during viral infection
• ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
• Integrative analysis unveils new functions for the Drosophila Cutoff protein in non-coding RNA biogenesis and gene regulation
• GuideScan software for improved single and paired CRISPR guide RNA design
• Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells
• Genome-Wide Detection and Analysis of Multifunctional Genes
• Classifications of protein roles in the functional organization of the cell
• Simple Topological Features Reflect Dynamics and Modularity in Protein Interaction Networks
• Empirical validation of the Buckley--Osthus model for the web host graph: degree and edge distributions
• Almost periodicity, finite automata mappings, and related effectiveness issues
• On uniformly recurrent morphic sequences
• Aperiodicity Measure for Infinite Sequences
• Sequences close to periodic
• On almost periodicity criteria for morphic sequences in some particular cases
• Information in Infinite Words
• Finite-automaton transformations of strictly almost-periodic sequences