Recent studies have advanced our understanding of chromosomal organization and its principal role in gene regulation. However, most analyses have focused on short-range interactions (
Inferring dynamic cellular processes from static single-cell measurements remains a central challenge in genomics. Here we introduce ArchVelo, a new method for modeling gene regulation and inferring cell trajectories using single-cell simultaneous …
T cells protect against pathogens and tumors and can differentiate into various functionally distinct subsets. While each subset exhibits a characteristic epigenomic and transcriptional profile, essential immune functions such as self-renewal, …
Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling. In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also …