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ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories

Inferring dynamic cellular processes from static single-cell measurements remains a central challenge in genomics. Here we introduce ArchVelo, a new method for modeling gene regulation and inferring cell trajectories using single-cell simultaneous …

Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection

T cells protect against pathogens and tumors and can differentiate into various functionally distinct subsets. While each subset exhibits a characteristic epigenomic and transcriptional profile, essential immune functions such as self-renewal, …

Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling. In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also …